Posterior Reversible Encephalopathy Syndrome (PRES) following gastrointestinal sepsis in a child: a case report.
5 affiliations
- 1Department of Anesthesiology and Intensive Care, University Hospital Center, Treichville, Abidjan, Côte d'Ivoire. [email protected].
- 2Félix Houphouët-Boigny University - UFR Sciences Médicales, Abidjan, Côte d'Ivoire. [email protected].
- 3Department of Anesthesiology and Intensive Care, University Hospital Center, Yopougon, Abidjan, Côte d'Ivoire.
- 4Félix Houphouët-Boigny University - UFR Sciences Médicales, Abidjan, Côte d'Ivoire.
- 5Department of Anesthesiology and Intensive Care, University Hospital Center, Treichville, Abidjan, Côte d'Ivoire.
Abstract
Background
Posterior Reversible Encephalopathy Syndrome (PRES) is a rare neurological entity in the paediatric population, whose diagnosis relies primarily on brain MRI. Although at-risk populations are well established, cases occurring in the context of sepsis of gastrointestinal origin are rare, particularly in paediatric intensive care settings in sub-Saharan Africa. Case presentationA 12-year-old girl with no medical history was admitted for peritonitis secondary to ileal perforation, managed after a two-week delay. The initial presentation combined severe sepsis, grade 2 arterial hypertension, acute kidney injury, severe hypoglycaemia and metabolic acidosis. Postoperatively, two haemodialysis sessions corrected renal function and resolved the choreiform movements and bruxism, whereas arterial hypertension and agitation persisted. On the tenth postoperative day, the onset of refractory seizures and bilateral cortical blindness prompted brain MRI, which revealed bilateral symmetrical parieto-occipital vasogenic oedema - involving the medial occipital lobes and the calcarine cortex - with cerebellar involvement and haemorrhagic stigmata on susceptibility-weighted sequences, confirming the diagnosis of PRES. Intravenous nicardipine and levetiracetam were initiated. The outcome was favourable, with complete neurological recovery and full visual restitution after 65 days.Conclusion
This case illustrates the diagnostic complexity of PRES in paediatric intensive care within a resource-limited setting. It suggests that sepsis of gastrointestinal origin may contribute to the occurrence of PRES both directly and by initiating associated dysfunctions - arterial hypertension, acute kidney injury, hypovolaemia and uraemic encephalopathy - acting as contributory cofactors. The diagnosis of PRES was retained as predominant on the basis of brain imaging and clinical reversibility under treatment. Finally, this case underscores that the timeliness of diagnosis and management of the triggering factor - peritonitis - is an essential determinant of neurological outcome.
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BibTeX
@article{sai2026posterior,
title = {{Posterior Reversible Encephalopathy Syndrome (PRES) following gastrointestinal sepsis in a child: a case report.}},
author = {Servais Sontia Sai and Koffi Isidore Kouame and Lebailly Landry Kohou-Kone and Kouadio Antoine Kouame and Stephane Charles-Evrard Adingra and Narcisse Boua},
journal = {BMC anesthesiology},
year = {2026},
month = aug,
doi = {10.1186/s12871-026-04105-2},
url = {https://europepmc.org/article/MED/42958481},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Posterior Reversible Encephalopathy Syndrome (PRES) following gastrointestinal sepsis in a child: a case report.
AU - Servais Sontia Sai
AU - Koffi Isidore Kouame
AU - Lebailly Landry Kohou-Kone
AU - Kouadio Antoine Kouame
AU - Stephane Charles-Evrard Adingra
AU - Narcisse Boua
PY - 2026
DA - 2026/08/03
JO - BMC anesthesiology
DO - 10.1186/s12871-026-04105-2
UR - https://europepmc.org/article/MED/42958481
AB - Background Posterior Reversible Encephalopathy Syndrome (PRES) is a rare neurological entity in the paediatric population, whose diagnosis relies primarily on brain MRI. Although at-risk populations are well established, cases occurring in the context of sepsis of gastrointestinal origin are rare, particularly in paediatric intensive care settings in sub-Saharan Africa. Case presentationA 12-year-old girl with no medical history was admitted for peritonitis secondary to ileal perforation, managed after a two-week delay. The initial presentation combined severe sepsis, grade 2 arterial hypertension, acute kidney injury, severe hypoglycaemia and metabolic acidosis. Postoperatively, two haemodialysis sessions corrected renal function and resolved the choreiform movements and bruxism, whereas arterial hypertension and agitation persisted. On the tenth postoperative day, the onset of refractory seizures and bilateral cortical blindness prompted brain MRI, which revealed bilateral symmetrical parieto-occipital vasogenic oedema - involving the medial occipital lobes and the calcarine cortex - with cerebellar involvement and haemorrhagic stigmata on susceptibility-weighted sequences, confirming the diagnosis of PRES. Intravenous nicardipine and levetiracetam were initiated. The outcome was favourable, with complete neurological recovery and full visual restitution after 65 days.Conclusion This case illustrates the diagnostic complexity of PRES in paediatric intensive care within a resource-limited setting. It suggests that sepsis of gastrointestinal origin may contribute to the occurrence of PRES both directly and by initiating associated dysfunctions - arterial hypertension, acute kidney injury, hypovolaemia and uraemic encephalopathy - acting as contributory cofactors. The diagnosis of PRES was retained as predominant on the basis of brain imaging and clinical reversibility under treatment. Finally, this case underscores that the timeliness of diagnosis and management of the triggering factor - peritonitis - is an essential determinant of neurological outcome.
SN - 1471-2253
ER -