Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study
5 affiliations
- 1Guangdong Mental Health Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510030 Guangdong Province China
- 2The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China
- 3Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province, Ministry of Education of China, Guangzhou Medical University, Guangzhou, China
- 4Department of Clinical Psychology, Medical School, South China Hospital, Shenzhen University, Shenzhen, China
- 5Shenzhen Second People’s Hospital, Shenzhen, China
Abstract
Background: Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population.
Methods: We conducted a 6-month prospective cohort study of depressed youth recruited from a psychiatric hospital from January 2022 to December 2023. We examined the association between baseline insomnia severity and time to first suicide attempt using Kaplan–Meier curves and multivariable Cox proportional hazards models.
Results: A total of 561 participants were included in the final analysis (428 female participants [76.3%]). At baseline, 458 participants met the criteria for insomnia (Athens Insomnia Scale [AIS] ≥ 6; 81.6%). In multivariable Cox models, insomnia severity was associated with a small but statistically significant higher hazard of suicide attempts (HR = 1.07, 95% CI 1.01–1.13, p = 0.038). Kaplan–Meier curves also showed a significant difference in time to first suicide attempt between the insomnia and non-insomnia groups (p < 0.001). In addition, greater depressive severity (HR = 1.11, 95% CI 1.04–1.18, p = 0.002), and a lifetime history of suicidality (HR = 2.14, 95%CI 1.31–3.48, p = 0.004) predicted follow-up attempts, whereas a longer illness duration (>24 months) was associated with a lower hazard (HR = 0.34, 95% CI 0.17–0.69, p = 0.005).
Conclusions: Greater baseline insomnia severity was associated with an increased risk of subsequent suicide attempts in youth with depression. The findings support early identification and intervention for suicidal risk in this vulnerable population.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13034-026-01148-8.
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BibTeX
@article{fan2026insomnia,
title = {{Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study}},
author = {Xuefei Fan and Kunrong Lin and Ziyan Zhou and Xiaoming Lin and Yarong Ma and Jie Zhang and Hongbo He},
journal = {Child and Adolescent Psychiatry and Mental Health},
year = {2026},
month = aug,
doi = {10.1186/s13034-026-01148-8},
url = {https://doi.org/10.1186/s13034-026-01148-8},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study
AU - Xuefei Fan
AU - Kunrong Lin
AU - Ziyan Zhou
AU - Xiaoming Lin
AU - Yarong Ma
AU - Jie Zhang
AU - Hongbo He
PY - 2026
DA - 2026/08/02
JO - Child and Adolescent Psychiatry and Mental Health
DO - 10.1186/s13034-026-01148-8
UR - https://doi.org/10.1186/s13034-026-01148-8
AB - Background: Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population. Methods: We conducted a 6-month prospective cohort study of depressed youth recruited from a psychiatric hospital from January 2022 to December 2023. We examined the association between baseline insomnia severity and time to first suicide attempt using Kaplan–Meier curves and multivariable Cox proportional hazards models. Results: A total of 561 participants were included in the final analysis (428 female participants [76.3%]). At baseline, 458 participants met the criteria for insomnia (Athens Insomnia Scale [AIS] ≥ 6; 81.6%). In multivariable Cox models, insomnia severity was associated with a small but statistically significant higher hazard of suicide attempts (HR = 1.07, 95% CI 1.01–1.13, p = 0.038). Kaplan–Meier curves also showed a significant difference in time to first suicide attempt between the insomnia and non-insomnia groups (p < 0.001). In addition, greater depressive severity (HR = 1.11, 95% CI 1.04–1.18, p = 0.002), and a lifetime history of suicidality (HR = 2.14, 95%CI 1.31–3.48, p = 0.004) predicted follow-up attempts, whereas a longer illness duration (>24 months) was associated with a lower hazard (HR = 0.34, 95% CI 0.17–0.69, p = 0.005). Conclusions: Greater baseline insomnia severity was associated with an increased risk of subsequent suicide attempts in youth with depression. The findings support early identification and intervention for suicidal risk in this vulnerable population. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s13034-026-01148-8.
SN - 1753-2000
ER -