Ultrasound-assisted cloud point extraction of phenolamide from rose residues: optimization, characterization and molecular interactions
- 1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
- 2Shenzhen Key Laboratory of Food Nutrition and Health, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
- 3State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Corresponding authors at: State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China.
Abstract
Rose essential oil production generates large amounts of solid residues, which remain underutilized despite their richness in bioactive compounds. Profiling of the rose residues in this study identified N 1 , N 5 , N 1 0 -( E )-tri- p -coumaroylspermidine (ETCS), a representative bioactive phenolamide. Following that, an ultrasound-assisted cloud point extraction (UA-CPE) strategy was developed to recover ETCS from these residues. The optimized extraction conditions were 5% (w/v) Brij 58, a solid-to-liquid ratio of 1:40 (g/mL), and a nominal ultrasonic power of 480 W at 50 °C for 30 min. The ETCS yield reached 2.86 ± 0.15 mg/g, which was approximately 80% higher than that obtained by ultrasound-assisted ethanol extraction. Subsequent phase separation (10% (w/v) Na 2 SO 4 , pH 4.0, 35 °C) achieved a 7.1-fold concentration factor with 98% recovery. Greenness and practicality assessments using AGREE, AGREEprep, and BAGI indicated favorable greenness and laboratory-scale practicality of the developed method. Instrumental characterization and DFT calculations suggested that ETCS may associate with the relatively hydrophilic POE region of Brij 58. Overall, these findings support UA-CPE as an efficient strategy for the recovery and preconcentration of ETCS from rose residues, thereby contributing to the value-added utilization of rose byproducts.
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BibTeX
@article{chen2026ultrasoundassisted,
title = {{Ultrasound-assisted cloud point extraction of phenolamide from rose residues: optimization, characterization and molecular interactions}},
author = {Honglu Chen and Jin Qian and Shanshan Zhang and Jinxiang Chen and Ken Chen and Mingfu Wang and Qian Zhou and Haitao Li},
journal = {Ultrasonics Sonochemistry},
year = {2026},
month = oct,
doi = {10.1016/j.ultsonch.2026.108133},
url = {https://doi.org/10.1016/j.ultsonch.2026.108133},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Ultrasound-assisted cloud point extraction of phenolamide from rose residues: optimization, characterization and molecular interactions
AU - Honglu Chen
AU - Jin Qian
AU - Shanshan Zhang
AU - Jinxiang Chen
AU - Ken Chen
AU - Mingfu Wang
AU - Qian Zhou
AU - Haitao Li
PY - 2026
DA - 2026/10/22
JO - Ultrasonics Sonochemistry
DO - 10.1016/j.ultsonch.2026.108133
UR - https://doi.org/10.1016/j.ultsonch.2026.108133
AB - Rose essential oil production generates large amounts of solid residues, which remain underutilized despite their richness in bioactive compounds. Profiling of the rose residues in this study identified N 1 , N 5 , N 1 0 -( E )-tri- p -coumaroylspermidine (ETCS), a representative bioactive phenolamide. Following that, an ultrasound-assisted cloud point extraction (UA-CPE) strategy was developed to recover ETCS from these residues. The optimized extraction conditions were 5% (w/v) Brij 58, a solid-to-liquid ratio of 1:40 (g/mL), and a nominal ultrasonic power of 480 W at 50 °C for 30 min. The ETCS yield reached 2.86 ± 0.15 mg/g, which was approximately 80% higher than that obtained by ultrasound-assisted ethanol extraction. Subsequent phase separation (10% (w/v) Na 2 SO 4 , pH 4.0, 35 °C) achieved a 7.1-fold concentration factor with 98% recovery. Greenness and practicality assessments using AGREE, AGREEprep, and BAGI indicated favorable greenness and laboratory-scale practicality of the developed method. Instrumental characterization and DFT calculations suggested that ETCS may associate with the relatively hydrophilic POE region of Brij 58. Overall, these findings support UA-CPE as an efficient strategy for the recovery and preconcentration of ETCS from rose residues, thereby contributing to the value-added utilization of rose byproducts.
SN - 1350-4177
SN - 1873-2828
ER -