Molecular biology & gene regulation
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- Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability
- CellDiffusion: Enhancing scRNA-seq data integration with accurate inference of cell-cell association
- Muscle stem cells produce a protective Fibrillin-1 matrix to prevent precocious activation
- Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control
- Programmable and selective silencing of oncogenic fusion transcripts by CRISPR-Cas13b via breakpoint sequence recognition
- LitGene: an interpretable transformer model integrating text and ontology for gene representation learning
- A genetically encoded local learning rule enables physical learning in engineered bacteria
- Circulating chromatin reveals effects of disease-associated variants on gene regulation
- Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins
- ZFPM2 deficiency is associated with oxidative stress and autophagy via FoxO pathway suppression in cardiac development and heart failure
- Network pharmacology and metabolomics analysis of ginsenosides in fibrinolysis balance after hip arthroplasty
- Representation learning for low-data protein fitness prediction using sequence–structure embeddings and graph neural networks
- Identification of stable reference genes for quantitative real-time PCR in human fibroblasts from lymph nodes and synovium
- Atomistic insights into spermidine-mediated stabilization of paranemic crossover DNA motifs
- Integrative multi-omics reveals CUL4B as a modulator of macrophage pyroptosis and innate defense against Staphylococcus aureus
- SPRIZ (CCDC127) protein conserved in deuterostome animals is a rigid OMM–IMM tether that locally sets mitochondrial IMS volume
- A transcriptional cofactor GRIP1 drives PPARγ DNA binding and p300-dependent enhancer activity during homeostatic macrophage polarization
- The archibiome: extending engineered living materials to multiscale built environments
- Iron oxide nanoparticle-mediated elicitation enhances secondary metabolite production, antioxidant activity, and gene expression in Melia azedarach L
- Variable clinical course of retinitis pigmentosa patients with RPE65 gene mutations
- Untargeted metabolomics in microbiome-immune crosstalk in cancer: challenges and recommendations for functional interpretation
- Explainable artificial intelligence (XAI) in schizophrenia: enhancing transparency in clinical decision-making
- MambaGLA-NPC: a 3D framework integrating CNN and state space models for robust multi-center nasopharyngeal carcinoma segmentation
- TNRSim — a simulator of truncated oxford nanopore direct RNA long reads for isoform analysis
- Patient classification using single-cell RNA-sequencing data with deep learning convolutional neural networks