Polyketides from a soil -derived Streptomyces sp. CSDX076 and their antimicrobial activities
6 affiliations
- 1Guizhou Provincial Key Laboratory of Microbial Resources and Drug Development, Zunyi Medical University, Zunyi, Guizhou, China
- 2School of Stomatology, Zunyi Medical University, Zunyi, China
- 3Shool of Pharmacy, Zunyi Medical University, Zunyi, China
- 4Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan
- 5School of Basic Medical Sciences, Zunyi Medical University, Zunyi, China
- 6Yunnan Institute of Food Safety, Kunming University of Science and Technology, Zunyi, China
Abstract
A new naturally occurring polyketide, pseurotin A ₃ -10,11-acetonide (1), along with two known analogs, pseurotin A (2) and pseurotin A ₃ (3), was isolated from the culture broth of Streptomyces sp. CSDX076. The structures of these compounds were determined by extensive 1D and 2D nuclear magnetic resonance (NMR), ultraviolet (UV), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic analyses. All isolated compounds (1-3) were evaluated for antimicrobial activity against a panel of seven pathogenic strains using disc diffusion and broth microdilution methods. Notably, compound 1 exhibited moderate activity against Brucella melitensis with a minimum inhibitory concentration (MIC) of 8.0 μg/mL, while compound 2 showed weak activity against Staphylococcus epidermidis (MIC = 128.0 μg/mL); compound 3 was inactive against all tested strains. This study reports, for the first time, the antibacterial effects of these compounds against the respective pathogens.
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BibTeX
@article{qian2026polyketides,
title = {{Polyketides from a soil -derived Streptomyces sp. CSDX076 and their antimicrobial activities}},
author = {Shengyan Qian and Hengxing Cai and Afsar Khan and Bin Chen and Li Tuo and Guiguang Cheng},
journal = {PeerJ},
year = {2026},
month = oct,
doi = {10.7717/peerj.21830},
url = {https://peerj.com/articles/21830},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Polyketides from a soil -derived Streptomyces sp. CSDX076 and their antimicrobial activities
AU - Shengyan Qian
AU - Hengxing Cai
AU - Afsar Khan
AU - Bin Chen
AU - Li Tuo
AU - Guiguang Cheng
PY - 2026
DA - 2026/10/21
JO - PeerJ
DO - 10.7717/peerj.21830
UR - https://peerj.com/articles/21830
AB - A new naturally occurring polyketide, pseurotin A ₃ -10,11-acetonide (1), along with two known analogs, pseurotin A (2) and pseurotin A ₃ (3), was isolated from the culture broth of Streptomyces sp. CSDX076. The structures of these compounds were determined by extensive 1D and 2D nuclear magnetic resonance (NMR), ultraviolet (UV), and high-resolution electrospray ionization mass spectrometry (HRESIMS) spectroscopic analyses. All isolated compounds (1-3) were evaluated for antimicrobial activity against a panel of seven pathogenic strains using disc diffusion and broth microdilution methods. Notably, compound 1 exhibited moderate activity against Brucella melitensis with a minimum inhibitory concentration (MIC) of 8.0 μg/mL, while compound 2 showed weak activity against Staphylococcus epidermidis (MIC = 128.0 μg/mL); compound 3 was inactive against all tested strains. This study reports, for the first time, the antibacterial effects of these compounds against the respective pathogens.
SN - 2167-8359
ER -