Sterol-like natural products and other secondary metabolites with antimicrobial and antiplasmodial activities from Penicillium tanzanicum
7 affiliations
- 1Department of Chemistry, Higher Teacher Training College, University of Yaoundé I P.O. Box 47 Yaoundé Cameroon
- 2Department of Organic Chemistry, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé Cameroon
- 3Department of Chemistry, Faculty of Science, University of Buea P.O. Box 63 Buea Cameroon
- 4Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Universitätsstrasse 1 40225 Düsseldorf Germany
- 5Laboratory of Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaounde Cameroon
- 6Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena via A. Moro 2 Siena 53100 Italy
- 7H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi Karachi-75270 Pakistan
Abstract
A recent review on Penicillium species highlighted steroids as a taxonomic marker of this genus. In the current study, three steroids (1–3), an acetophenone (4), and thirteen known compounds (5–17) were isolated from the solid culture of Penicillium tanzanicum, isolated from bull dung. The structures of the compounds were established using extensive spectroscopic and spectrometric analyses (NMR, HRMS) and by comparison with published data. The absolute configurations of steroids 1–3 were determined by electronic circular dichroism (ECD) calculations, confirming their identities as trestione (1), formestane (2), and oxandrolone (3). The crude extract exhibited moderate activity against Mycobacterium tuberculosis (MIC = 400 µg mL−1) and significant activity against Enterococcus faecalis and E. faecium (MIC = 50 µg mL−1). Compounds 8, 9, 11, and 13 displayed weak to moderate antibacterial and antimycobacterial activities against M. tuberculosis, Staphylococcus aureus, E. faecalis, and E. faecium, with MIC values ranging from 50 to 100 µg mL−1. Notably, compounds 1 and 2 demonstrated promising antiplasmodial activity against the multi-resistant Plasmodium falciparum (PfDd2) strain, with IC50 values of 26.58 and 15.03 µM, respectively, accompanied by low haemolytic effects. These findings underscore the potential of fungi from underexplored ecological niches as sources of new anti-infective leads warranting further optimisation and preclinical evaluation.
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BibTeX
@article{tchamgoue2026sterollike,
title = {{Sterol-like natural products and other secondary metabolites with antimicrobial and antiplasmodial activities from Penicillium tanzanicum}},
author = {Joseph Tchamgoue and Bel Youssouf G. Mountessou and Terence Yocktan D. Yepdjou and Aron Trucksess and Lasse van Geelen and Kevin Jordan N. Tchoffo and Mariscal Brice T. Tali and Simone Veglianti and Daniele Padula and Ayaz Ahmed and Rainer Kalscheuer and Simeon F. Kouam},
journal = {RSC advances},
year = {2026},
month = oct,
doi = {10.1039/d6ra06849a},
url = {https://europepmc.org/article/PMC/PMC13656012},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Sterol-like natural products and other secondary metabolites with antimicrobial and antiplasmodial activities from Penicillium tanzanicum
AU - Joseph Tchamgoue
AU - Bel Youssouf G. Mountessou
AU - Terence Yocktan D. Yepdjou
AU - Aron Trucksess
AU - Lasse van Geelen
AU - Kevin Jordan N. Tchoffo
AU - Mariscal Brice T. Tali
AU - Simone Veglianti
AU - Daniele Padula
AU - Ayaz Ahmed
AU - Rainer Kalscheuer
AU - Simeon F. Kouam
PY - 2026
DA - 2026/10/12
JO - RSC advances
DO - 10.1039/d6ra06849a
UR - https://europepmc.org/article/PMC/PMC13656012
AB - A recent review on Penicillium species highlighted steroids as a taxonomic marker of this genus. In the current study, three steroids (1–3), an acetophenone (4), and thirteen known compounds (5–17) were isolated from the solid culture of Penicillium tanzanicum, isolated from bull dung. The structures of the compounds were established using extensive spectroscopic and spectrometric analyses (NMR, HRMS) and by comparison with published data. The absolute configurations of steroids 1–3 were determined by electronic circular dichroism (ECD) calculations, confirming their identities as trestione (1), formestane (2), and oxandrolone (3). The crude extract exhibited moderate activity against Mycobacterium tuberculosis (MIC = 400 µg mL−1) and significant activity against Enterococcus faecalis and E. faecium (MIC = 50 µg mL−1). Compounds 8, 9, 11, and 13 displayed weak to moderate antibacterial and antimycobacterial activities against M. tuberculosis, Staphylococcus aureus, E. faecalis, and E. faecium, with MIC values ranging from 50 to 100 µg mL−1. Notably, compounds 1 and 2 demonstrated promising antiplasmodial activity against the multi-resistant Plasmodium falciparum (PfDd2) strain, with IC50 values of 26.58 and 15.03 µM, respectively, accompanied by low haemolytic effects. These findings underscore the potential of fungi from underexplored ecological niches as sources of new anti-infective leads warranting further optimisation and preclinical evaluation.
SN - 2046-2069
ER -