Uncovering diversity and bioactivity of mangrove Actinomycetia through systematic analysis
- 1Faculty of Ocean Science and Technology, Kerala University of Fisheries and Ocean Studies
- 2National Centre for Aquatic Animal Health (NCAAH), Lakeside Campus, Cochin University of Science and Technology Fine Arts Avenue
- 3Department of Marine Biology, Microbiology and Biochemistry, Cochin University of Science and Technology
Abstract
Mangrove ecosystems, between the terrestrial and marine domain, harbor a diverse and specialized microbial community, including Actinomycetia members, which produce a variety of functionally distinct bioactive metabolites. Molecular and genomic approaches have enabled the investigation of Actinomycetial diversity and identification of new strains and secondary metabolites. Mangrove-associated Actinomycetia from diverse areas have been reported in many studies. However, several habitats can still be poorly studied, hence their diversity and biosynthetic potential is lacking. This review systematically aims to highlight the study of the taxonomical diversity as well as bioactive potentials of Mangrove-associated Actinomycetia from sediments and endophytic niches from the study records published between 1988 and 2025. The integrated literature shows that these microorganisms generate diverse metabolites with antimicrobial, anticancer, antioxidant, quorum-quenching, and antibiofilm effects. Because of differences in the specific environmental conditions in mangrove ecosystems (salinity variation, tidal activities and nutrient gradients), the microbial population behaviour, adaptation and production of secondary metabolites are expected to be altered due to the particular environmental scenarios of mangrove ecosystem. Mangrove-associated Actinomycetia represent a valuable yet underexplored resource for natural product discovery. Combining established isolation methods with genetic sequencing, metabolomics and other omics based methods would be fundamental for harnessing full biosynthetic potential, allowing the discovery of new and original bioactive compounds even more quickly.
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BibTeX
@article{james2026uncovering,
title = {{Uncovering diversity and bioactivity of mangrove Actinomycetia through systematic analysis}},
author = {Greeshma James and Rojin Joseph and Sajeevan Thavarool Puthiyedathu and Rejish Kumar Vattiringal Jayadradhan},
journal = {Discover Oceans},
year = {2026},
month = oct,
doi = {10.1007/s44289-026-00176-8},
url = {https://doi.org/10.1007/s44289-026-00176-8},
note = {CC BY},
}
RIS
TY - JOUR
TI - Uncovering diversity and bioactivity of mangrove Actinomycetia through systematic analysis
AU - Greeshma James
AU - Rojin Joseph
AU - Sajeevan Thavarool Puthiyedathu
AU - Rejish Kumar Vattiringal Jayadradhan
PY - 2026
DA - 2026/10/25
JO - Discover Oceans
DO - 10.1007/s44289-026-00176-8
UR - https://doi.org/10.1007/s44289-026-00176-8
AB - Mangrove ecosystems, between the terrestrial and marine domain, harbor a diverse and specialized microbial community, including Actinomycetia members, which produce a variety of functionally distinct bioactive metabolites. Molecular and genomic approaches have enabled the investigation of Actinomycetial diversity and identification of new strains and secondary metabolites. Mangrove-associated Actinomycetia from diverse areas have been reported in many studies. However, several habitats can still be poorly studied, hence their diversity and biosynthetic potential is lacking. This review systematically aims to highlight the study of the taxonomical diversity as well as bioactive potentials of Mangrove-associated Actinomycetia from sediments and endophytic niches from the study records published between 1988 and 2025. The integrated literature shows that these microorganisms generate diverse metabolites with antimicrobial, anticancer, antioxidant, quorum-quenching, and antibiofilm effects. Because of differences in the specific environmental conditions in mangrove ecosystems (salinity variation, tidal activities and nutrient gradients), the microbial population behaviour, adaptation and production of secondary metabolites are expected to be altered due to the particular environmental scenarios of mangrove ecosystem. Mangrove-associated Actinomycetia represent a valuable yet underexplored resource for natural product discovery. Combining established isolation methods with genetic sequencing, metabolomics and other omics based methods would be fundamental for harnessing full biosynthetic potential, allowing the discovery of new and original bioactive compounds even more quickly.
SN - 2948-1562
ER -