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Peer-reviewedCC BYGels (Basel, Switzerland)

Cyclodextrin-Containing Tannic Acid-Lipoic Acid Hydrogels for the Loading and Reduction-Responsive Release of Nile Red.

  • Yuzheng Zhu1
  • Kazuya U Kobayashi2
  • Akihiko Hatano3
  • Manabu Suzuki4
  • Kenichi Niikura1
4 affiliations
  1. 1Environmental Symbiotic System Major, Graduate School, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan.
  2. 2Department of Mechanical Engineering, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan.
  3. 3Department of Chemistry, Shibaura Institute of Technology, Fukasaku, Minumaku, Saitama-City 337-8570, Saitama, Japan.
  4. 4Research & Development Center for Advanced Materials and Technology, Nippon Institute of Technology, Miyashiro 345-8501, Saitama, Japan.
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Abstract

Hydrophobic molecules are generally difficult to incorporate into aqueous hydrogels because of their poor water solubility. In this study, a cyclodextrin (CD)-containing tannic acid-lipoic acid (TA-LA) hydrogel was developed using lipoic acid-modified β-cyclodextrin (LACD). LACD retained the host-guest recognition ability of the cyclodextrin cavity after lipoic acid modification and was successfully incorporated into the TA-LA hydrogel without interfering with gel formation. Using Nile Red (NR) as a model hydrophobic molecule, the LACD-containing hydrogel showed higher NR encapsulation efficiency and greater cyclodextrin retention than the hydrogel containing unmodified β-cyclodextrin. The LACD-containing hydrogel also exhibited reduction-responsive NR release in the presence of dithiothreitol (DTT). These results show that LACD can be incorporated into the TA-LA hydrogel while retaining the host-guest recognition ability of the cyclodextrin cavity and can be used for reduction-responsive release of NR.

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Cite

BibTeXRIS
BibTeX
@article{zhu2026cyclodextrincontaining,
  title = {{Cyclodextrin-Containing Tannic Acid-Lipoic Acid Hydrogels for the Loading and Reduction-Responsive Release of Nile Red.}},
  author = {Yuzheng Zhu and Kazuya U Kobayashi and Akihiko Hatano and Manabu Suzuki and Kenichi Niikura},
  journal = {Gels (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/gels12100868},
  url = {https://europepmc.org/article/MED/42929903},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Cyclodextrin-Containing Tannic Acid-Lipoic Acid Hydrogels for the Loading and Reduction-Responsive Release of Nile Red.
AU  - Yuzheng Zhu
AU  - Kazuya U Kobayashi
AU  - Akihiko Hatano
AU  - Manabu Suzuki
AU  - Kenichi Niikura
PY  - 2026
DA  - 2026/09/25
JO  - Gels (Basel, Switzerland)
DO  - 10.3390/gels12100868
UR  - https://europepmc.org/article/MED/42929903
AB  - Hydrophobic molecules are generally difficult to incorporate into aqueous hydrogels because of their poor water solubility. In this study, a cyclodextrin (CD)-containing tannic acid-lipoic acid (TA-LA) hydrogel was developed using lipoic acid-modified β-cyclodextrin (LACD). LACD retained the host-guest recognition ability of the cyclodextrin cavity after lipoic acid modification and was successfully incorporated into the TA-LA hydrogel without interfering with gel formation. Using Nile Red (NR) as a model hydrophobic molecule, the LACD-containing hydrogel showed higher NR encapsulation efficiency and greater cyclodextrin retention than the hydrogel containing unmodified β-cyclodextrin. The LACD-containing hydrogel also exhibited reduction-responsive NR release in the presence of dithiothreitol (DTT). These results show that LACD can be incorporated into the TA-LA hydrogel while retaining the host-guest recognition ability of the cyclodextrin cavity and can be used for reduction-responsive release of NR.
SN  - 2310-2861
ER  -