Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 23 min ago
Peer-reviewedCC BY-NC-NDCancer diagnosis & prognosis

Granular Cell Tumor of the Gallbladder: A Rare Entity.

  • Anja Stadnik1
  • Arijana Pačić1
  • Karolina Krstanac1
  • Kristina Lalić2
  • Domagoj Vergles3
  1. 1Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia.
  2. 2Department of Pulmonology, Dubrava University Hospital, Zagreb, Croatia.
  3. 3Division of Abdominal Surgery, Dubrava University Hospital, Zagreb, Croatia.
Read full textPDFDOICite

Abstract

Background/aim

Granular cell tumor (GCT) is a rare, typically benign neoplasm most likely derived from Schwann cells. GCTs occur in the biliary tract in less than 1% of cases, with the gallbladder being the least common location for this tumor.Case report

We report a case of a 37-year-old female who presented with persistent biliary colic. Histopathological analysis revealed a polypoid lesion in the gallbladder composed of large polygonal cells with abundant, eosinophilic, granular cytoplasm. Immunohistochemical staining showed positivity for S-100, SOX10 and focally positive for CD68 confirming the diagnosis of a benign GCT.Conclusion

GCT of the gallbladder is an exceptionally rare entity, with this representing only the tenth reported case in the literature. These tumors frequently mimic more common conditions such as cholecystitis, often presenting as biliary colic. Despite its rarity, GCT should be included in the differential diagnosis of gallbladder lesions, especially in younger populations.

Related

  1. Solitary cerebellopontine angle metastasis from gallbladder adenocarcinoma: A rare clinical entity.
    Manish Chaurasiya, Sandeep Bhardwaj
    Surgical neurology internationalPeer-reviewedCC BY-NC-SAFull textGeneral medicineEurope PMCPMC
  2. Surgical management of a rare bronchial granular cell tumor: a case report
    Yilun Wang, Yaojing Zhang, Hongcan Shi
    Journal of surgical case reportsPeer-reviewedCC BY-NCFull textSurgery & anaesthesiaEurope PMCPMC
  3. Vanek’s Tumor of the Jejunum Presenting as Adult Intussusception: A Rare Surgical Entity
    Mahesh Jadhav, Gowri Sanjay, Madhuri Tribhuvan +2
    Annals of African MedicinePeer-reviewedCC BY-NC-SA 4.0Full textSurgery & anaesthesiaPMC
  4. Histologically Confirmed Brain Metastasis Arising From Giant Cell Tumor of Bone: an Uncommon Entity and a Challenging Condition.
    Arthur Claessens, Sophie Martin, Victoire Thiebaut +3
    The American journal of case reportsPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  5. Perianal granular cell tumor misdiagnosed as anal fistula: a case report and literature re-view
    Ruan Jinwei, Liu Zhengkang, Yang Tingting
    结直肠肛门外科Peer-reviewedCC BY-NC-NDFull textSurgery & anaesthesiaDOAJ

Cite

BibTeXRIS
BibTeX
@article{stadnik2026granular,
  title = {{Granular Cell Tumor of the Gallbladder: A Rare Entity.}},
  author = {Anja Stadnik and Arijana Pačić and Karolina Krstanac and Kristina Lalić and Domagoj Vergles},
  journal = {Cancer diagnosis \& prognosis},
  year = {2026},
  month = nov,
  doi = {10.21873/cdp.10605},
  url = {https://europepmc.org/article/MED/42968930},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Granular Cell Tumor of the Gallbladder: A Rare Entity.
AU  - Anja Stadnik
AU  - Arijana Pačić
AU  - Karolina Krstanac
AU  - Kristina Lalić
AU  - Domagoj Vergles
PY  - 2026
DA  - 2026/11/01
JO  - Cancer diagnosis & prognosis
DO  - 10.21873/cdp.10605
UR  - https://europepmc.org/article/MED/42968930
AB  - Background/aim  Granular cell tumor (GCT) is a rare, typically benign neoplasm most likely derived from Schwann cells. GCTs occur in the biliary tract in less than 1% of cases, with the gallbladder being the least common location for this tumor.Case report  We report a case of a 37-year-old female who presented with persistent biliary colic. Histopathological analysis revealed a polypoid lesion in the gallbladder composed of large polygonal cells with abundant, eosinophilic, granular cytoplasm. Immunohistochemical staining showed positivity for S-100, SOX10 and focally positive for CD68 confirming the diagnosis of a benign GCT.Conclusion  GCT of the gallbladder is an exceptionally rare entity, with this representing only the tenth reported case in the literature. These tumors frequently mimic more common conditions such as cholecystitis, often presenting as biliary colic. Despite its rarity, GCT should be included in the differential diagnosis of gallbladder lesions, especially in younger populations.
SN  - 2732-7787
ER  -