Peer-reviewedCC BY-NC-NDInternal Medicine
Oral Doxycycline Plus Low-dose Hydroxychloroquine Following Intravenous Ceftriaxone may be Effective for Whipple's Disease in Japan : A Case Report and Literature Review
Abstract
A 52-year-old woman presented with weight loss and fever of unknown origin that had persisted for one year. She presented with multiple lymphadenopathies, primarily within the abdominal cavity, but no joint symptoms were observed. A second upper endoscopy revealed diffuse white shaggy villi in the duodenum and the ileum. A definitive diagnosis of Whipple's disease was made based on electron microscopy and polymerase chain reaction (PCR) of the biopsy specimen. Treatment was initiated with doxycycline plus low-dose hydroxychloroquine oral therapy, followed by ceftriaxone intravenous infusion. Ten months after treatment, the patient responded successfully with no side effects.
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BibTeX
@article{matsumura2026oral,
title = {{Oral Doxycycline Plus Low-dose Hydroxychloroquine Following Intravenous Ceftriaxone may be Effective for Whipple's Disease in Japan : A Case Report and Literature Review}},
author = {Norihiro Matsumura and Hideki Ishizu and Hidenori Kaihara and Yoshikazu Moriya and Tomonori Takano and Yuki Suzuki and Hisakazu Yano and Hiroyuki Kunishima},
journal = {Internal Medicine},
year = {2026},
month = jul,
doi = {10.2169/internalmedicine.7689-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7689-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Oral Doxycycline Plus Low-dose Hydroxychloroquine Following Intravenous Ceftriaxone may be Effective for Whipple's Disease in Japan : A Case Report and Literature Review
AU - Norihiro Matsumura
AU - Hideki Ishizu
AU - Hidenori Kaihara
AU - Yoshikazu Moriya
AU - Tomonori Takano
AU - Yuki Suzuki
AU - Hisakazu Yano
AU - Hiroyuki Kunishima
PY - 2026
DA - 2026/07/25
JO - Internal Medicine
DO - 10.2169/internalmedicine.7689-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7689-26/_article
AB - A 52-year-old woman presented with weight loss and fever of unknown origin that had persisted for one year. She presented with multiple lymphadenopathies, primarily within the abdominal cavity, but no joint symptoms were observed. A second upper endoscopy revealed diffuse white shaggy villi in the duodenum and the ileum. A definitive diagnosis of Whipple's disease was made based on electron microscopy and polymerase chain reaction (PCR) of the biopsy specimen. Treatment was initiated with doxycycline plus low-dose hydroxychloroquine oral therapy, followed by ceftriaxone intravenous infusion. Ten months after treatment, the patient responded successfully with no side effects.
SN - 1349-7235
SN - 0918-2918
ER -